I've ran 600 holleys and rochesters on 253s and 308s on gas as others have said both are good if tuned properly I've never driven a 253 with a standard 2 barrel is there much difference
I remember getting in a new VC (Blue motor with Rochester Carb) and being impressed with how much more go it had over the red motor and returned better real world fuel economy as well. It was a big improvement over the 2 barrel
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